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Also the patient is supposed to inform his physician when he takes antidepressants like fluoxetine or paroxetine together with this medication.

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Although the efficacy of paroxetine hydrochloride beyond 12 weeks of dosing has not been demonstrated in controlled clinical trials, social anxiety disorder is recognized as a chronic condition, and it is reasonable to consider continuation of treatment for a responding patient.

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In 1 study, daily dosing of immediate-release paroxetine 20 mg once daily under steady-state conditions increased single-dose desipramine 100 mg c max , auc, and t by an average of approximately 2-, 5-, and 3-fold, respectively.

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